Autophagy: a core cellular process with emerging links to pulmonary disease

TitleAutophagy: a core cellular process with emerging links to pulmonary disease
Publication TypeJournal Article
Year of Publication2011
AuthorsHaspel JA, Choi AMK
JournalAm J Respir Crit Care Med
Volume184
Issue11
Pagination1237-46
Date Published2011 Dec 1
ISSN1535-4970
KeywordsAutophagy, Cystic Fibrosis, Humans, Lung, Lung Diseases, Pulmonary Disease, Chronic Obstructive, Tuberculosis
Abstract

Autophagy is a highly conserved homeostatic pathway by which cells transport damaged proteins and organelles to lysosomes for degradation. Dysregulation of autophagy contributes to the pathogenesis of clinically important disorders in a variety of organ systems but, until recently, little was known about its relationship to diseases of the lung. However, there is now growing evidence at the basic research level that autophagy is linked to the pathogenesis of important pulmonary disorders such as chronic obstructive pulmonary disease, cystic fibrosis, and tuberculosis. In this review, we provide an introduction to the field of autophagy research geared to clinical and research pulmonologists. We focus on the best-studied autophagic mechanism, macroautophagy, and summarize studies that link the regulation of this pathway to pulmonary disease. Last, we offer our perspective on how a better understanding of macroautophagy might be used for designing novel therapies for pulmonary disorders.

DOI10.1164/rccm.201106-0966CI
Alternate JournalAm. J. Respir. Crit. Care Med.
PubMed ID21836133
PubMed Central IDPMC3262043
Grant ListR03 HL097005 / HL / NHLBI NIH HHS / United States
T32 HL007633 / HL / NHLBI NIH HHS / United States