Clinical significance of radiologic characterizations in COPD.

TitleClinical significance of radiologic characterizations in COPD.
Publication TypeJournal Article
Year of Publication2009
AuthorsHan MLK, Bartholmai B, Liu LX, Murray S, Curtis JL, Sciurba FC, Kazerooni EA, Thompson B, Frederick M, Li D, Schwarz M, Limper A, Freeman C, Landreneau RJ, Wise R, Martinez FJ
JournalCOPD
Volume6
Issue6
Pagination459-67
Date Published2009 Dec
ISSN1541-2563
KeywordsAge Factors, Aged, Body Mass Index, Cohort Studies, Dyspnea, Exercise Tolerance, Female, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Poisson Distribution, Predictive Value of Tests, Prognosis, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Pulmonary Gas Exchange, Respiratory Function Tests, Risk Assessment, Severity of Illness Index, Sex Factors, Tomography, X-Ray Computed
Abstract

COPD is a heterogeneous disorder with clinical assessment becoming increasingly multidimensional. We hypothesized HRCT phenotype would strongly influence clinical outcomes including health status, exacerbation frequency, and BODE. COPD subjects were characterized via the SF-12, SGRQ, MMRC, physiologic testing, and standardized volumetric chest HRCT. Visual semi-quantitative estimation of bronchial wall thickness (VBT) and automated quantification of emphysema percent and bronchial wall thickness were generated. Multivariate modeling compared emphysema severity and airway abnormality with clinical outcome measures. Poisson models were used to analyze exacerbation frequency. SGRQ and SF-12 physical component scores were influenced by FEV(1)% predicted, emphysema percent, and VBT. VBT scores > 2 (scale 0-48) were associated with increased exacerbation frequency (p = 0.009) in the preceding year adjusting for age, gender, emphysema percent, smoking history and FEV(1)% predicted, although this effect was attenuated by age. Emphysema percent correlated with total BODE score in unadjusted (r = 0.73; p

DOI10.3109/15412550903341513
Alternate JournalCOPD
PubMed ID19938970
Grant ListK24 HL004212 / HL / NHLBI NIH HHS / United States
K24 HL04212 / HL / NHLBI NIH HHS / United States
KL2 RR024987 / RR / NCRR NIH HHS / United States
N01 HR46158 / HR / NHLBI NIH HHS / United States
N01 HR46160 / HR / NHLBI NIH HHS / United States
N01 HR46161 / HR / NHLBI NIH HHS / United States
N01 HR46162 / HR / NHLBI NIH HHS / United States
N01 HR46164 / HR / NHLBI NIH HHS / United States
N01HR46163 / HR / NHLBI NIH HHS / United States
P50 HL084948 / HL / NHLBI NIH HHS / United States
R01 HL082480 / HL / NHLBI NIH HHS / United States
R01 HL082480 / HL / NHLBI NIH HHS / United States