Conclusions

A preliminary power analysis has been performed for the LTRC. It has been found that the proposed number of participants (N = approximately 1600) is sufficient to allow for small to moderate effects to be detected with adequate power (at least 80%) when testing at the alpha level of 0.05 (two-sided tests) and for larger effect sizes if subgroup analyses are to be performed.

The LTRC offers a unique opportunity to incorporate variables depicting cellular morphology differences, lung morphology differences, lung tissue biochemical differences and genetic differences of different diseases to show how these variables impact the progression of the various lung diseases. The models presented here are general and robust enough to allow important research to be done in this area.

 

 

 

 

 

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