Correlation of regional emphysema and lung cancer: a lung tissue research consortium-based study

TitleCorrelation of regional emphysema and lung cancer: a lung tissue research consortium-based study
Publication TypeJournal Article
Year of Publication2014
AuthorsHohberger LA, Schroeder DR, Bartholmai BJ, Yang P, Wendt CH, Bitterman PB, Larsson O, Limper AH
JournalJ Thorac Oncol
Volume9
Issue5
Pagination639-45
Date Published2014 May
ISSN1556-1380
KeywordsAged, Carcinoma, Non-Small-Cell Lung, Databases, Factual, Female, Humans, Lung Neoplasms, Male, Middle Aged, Pulmonary Emphysema, Risk Factors, Severity of Illness Index, Small Cell Lung Carcinoma, Smoking, Solitary Pulmonary Nodule, Tomography, X-Ray Computed
Abstract

BACKGROUND: Chronic obstructive pulmonary disease and lung cancer are linked because both airflow obstruction and emphysema, on computer tomography, are independent risk factors for lung cancer. However, the local risk of malignancy relative to development of regional emphysema has not yet been defined. Specifically, it is not known if primary lung cancers are associated with regions of worse emphysema within individual patients.

METHODS: We performed a database analysis evaluating the association between the degree of regional emphysema as scored on computer tomography and development of primary lung cancer. We also studied the association between regional emphysema and benign lung nodules. We assembled two distinct cohorts using the National Heart, Lung, and Blood Institute's Lung Tissue Research Consortium database, hypothesizing that lung malignancy will preferentially locate in the regions of the most severe emphysema.

RESULTS: In the Lung Tissue Research Consortium database, 624 cases met criteria for the malignant nodule cohort and 64 were included in the benign nodule cohort. When comparing location of a malignant nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of lung cancer was 1.342 (95% confidence interval 1.112-1.620; p = 0.0022). When comparing location of a benign nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of the benign nodule was 1.118 (95% confidence interval 0.725-1.725; p = 0.6137).

CONCLUSIONS: Primary lung cancers are associated with areas of worse regional emphysema.

DOI10.1097/JTO.0000000000000144
Alternate JournalJ Thorac Oncol
PubMed ID24662456
PubMed Central IDPMC3984592
Grant ListN01 HR46161-06 / HR / NHLBI NIH HHS / United States
N01HR46161 / HL / NHLBI NIH HHS / United States
R01 CA080127 / CA / NCI NIH HHS / United States
R01 CA084354 / CA / NCI NIH HHS / United States
R01 CA115857 / CA / NCI NIH HHS / United States
R01 HL107612 / HL / NHLBI NIH HHS / United States
R01HL107612-01 / HL / NHLBI NIH HHS / United States
UL1 TR000135 / TR / NCATS NIH HHS / United States