|Title||Gender influences Health-Related Quality of Life in IPF.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Han MLK, Swigris J, Liu L, Bartholmai B, Murray S, Giardino N, Thompson B, Frederick M, Li D, Schwarz M, Limper A, Flaherty K, Martinez FJ|
|Date Published||2010 May|
|Keywords||Dyspnea, Female, Health Status, Humans, Idiopathic Pulmonary Fibrosis, Linear Models, Male, Middle Aged, Quality of Life, Sex Factors, Sickness Impact Profile, Surveys and Questionnaires, Treatment Outcome|
BACKGROUND: HRQL in IPF patients is impaired. Data from other respiratory diseases led us to hypothesize that significant gender differences in HRQL in IPF also exist.
METHODS: Data were drawn from the NIH-sponsored Lung Tissue Research Consortium (LTRC). Demographic and pulmonary physiology data along with MMRC, SF-12, and SGRQ scores from women vs. men were compared with two-sample t-tests. Multivariate linear regression was used to examine the association between SF-12 component scores and gender while adjusting for other relevant variables.
RESULTS: The study sample consisted of 147 men and 74 women. Among several baseline variables, only DL(CO)% predicted differed between women and men, (43.7 vs. 38.0, p=0.03). In general, men exhibited lower (better) MMRC scores (1.7 vs. 2.4, p=0.02), particularly those with milder disease as measured by DL(CO)% predicted. In an adjusted analysis, SF-12 PCS scores in men were lower (worse) than women (p=0.01), an effect that was more pronounced in men with greater dyspnea scores. In a similar analysis, SF-12 MCS scores in women were lower than men (worse) (48.3 vs. 54.4, p=0.0004), an effect that was more pronounced in women with greater dyspnea scores.
CONCLUSIONS: Significant gender differences in HRQL exist in IPF. As compared to women, men reported less severe dyspnea, had worse SF-12 PCS scores, but better SF-12 MCS scores. Dyspnea appears to have a greater impact on the physical HRQL of men and the emotional HRQL of women. An improved understanding of the mechanism behind these differences is needed to better target interventions.
|Alternate Journal||Respir Med|
|PubMed Central ID||PMC2862780|
|Grant List||K23 HL092227 / HL / NHLBI NIH HHS / United States |
K23 HL093351 / HL / NHLBI NIH HHS / United States
K23 HL093351-01A1 / HL / NHLBI NIH HHS / United States
K24 HL004212 / HL / NHLBI NIH HHS / United States
K24 HL04212 / HL / NHLBI NIH HHS / United States
KL2 RR024987 / RR / NCRR NIH HHS / United States
N01 HR46158 / HR / NHLBI NIH HHS / United States
N01 HR46160 / HR / NHLBI NIH HHS / United States
N01 HR46161 / HR / NHLBI NIH HHS / United States
N01 HR46162 / HR / NHLBI NIH HHS / United States
N01 HR46164 / HR / NHLBI NIH HHS / United States