LTRC Protocol CT Scan

A volumetric high-resolution CT scan protocol of the chest will be obtained specifically for research purposes, with two acquisitions of images including supine inspiratory and supine expiratory imaging with specific acquisition parameters and multiple reconstructions to optimize diagnostic utility and consistency in quantitative analysis (Only for the LTRC II study).

The LTRC CT Scan is the preferred CT scan protocol to be collected for phenotyping the subject in the LTRC. The LTRC CT Scan is designed specifically to allow quantitative analysis of the lung as part of the LTRC project, and requires specific acquisition and reconstruction parameters that enable data to be as comparable as possible between the different subjects.

A subset of the CT scanners available at the Clinical Centers will be certified for use in obtaining this specific LTRC CT scan trial through an ongoing QA assessment and Protocol validation process. The precise parameters used for obtaining this LTRC CT dataset will be optimized for each specific CT scanner at a Clinical Center. Specifically, the full LTRC CT Scan Protocol will consist of two helically acquired datasets on a multidetector CT scanner (with no less than 16 detectors) as well as scout/localization images as needed.

Thin-slice images (1.0 mm or less) will be obtained and reconstructed at 50% overlap in both a high-resolution kernel (with specific accommodation for this kernel's density accuracy) and a kernel with lower noise and spatial frequency. These scans will be obtained in the supine position at full inspiration and suspended full expiration. Scans will be optimized to allow for single breath acquisition in less than 10 seconds.

Radiation dose will be adjusted for the participant's size. The ALARA (as low as reasonably allowable) principle will be utilized in these studies with accommodation for the adequate signal/noise ratio to realize the experimental quantitative analysis goals of the LTRC. The effective dose for the inspiratory phase LTRC CT Scan will be approximately 3-5 millisieverts (mSv), and a lower dose expiratory phase will be approximately 2-3 mSv.

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