|Title||Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Berry CE, M Drummond B, Han MLK, Li D, Fuller C, Limper AH, Martinez FJ, Schwarz MI, Sciurba FC, Wise RA|
|Date Published||2012 Sep|
|Keywords||Aged, Disease Progression, Female, Forced Expiratory Volume, Humans, Intelligence Tests, Linear Models, Lung, Lung Diseases, Interstitial, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Quality of Life, Respiratory Function Tests, Severity of Illness Index|
BACKGROUND: Health-related quality-of-life (HRQL) measures have been correlated with lung function in patients with COPD and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment.
METHODS: The National Heart, Lung, and Blood Institute Lung Tissue Research Consortium provided data on well-characterized participants with COPD (n = 576) and ILD (n = 405) at four clinical sites. Using multiple linear regression, we examined the effects of FEV₁ (% predicted) and diagnosis (ILD vs COPD) on HRQL scores, including total St. George Respiratory Questionnaire (SGRQ) scores and Short Form-12 (SF-12) physical component summary (PCS) and mental component summary (MCS) scores.
RESULTS: Participants with ILD had, on average, higher SGRQ scores (15.33 points; 95% CI, 12.46-18.19; P <.001) and lower SF-12 PCS scores (-4.73 points; 95% CI, -6.31 to -3.14; P <.001) compared with patients with COPD with similar FEV₁ % predicted values, indicating worse HRQL. The specific diagnosis also modified the effect of FEV₁ on the total SGRQ score (P = .003) and the SF-12 PCS score (P = .03). There was no relationship between lung function and SF-12 MCS scores.
CONCLUSIONS: HRQL scores were worse for patients with ILD compared with patients with COPD with similar degrees of ventilatory impairment. Differences in dyspnea mechanism or in the rate of disease progression may account for these differences in HRQL.
|PubMed Central ID||PMC3435139|
|Grant List||1KL2RR025006-01 / RR / NCRR NIH HHS / United States |
K23 HL093351 / HL / NHLBI NIH HHS / United States
K23 HL103192 / HL / NHLBI NIH HHS / United States
N01-HR-46164 / HR / NHLBI NIH HHS / United States
T32 HL007534 / HL / NHLBI NIH HHS / United States
UL1 RR024153 / RR / NCRR NIH HHS / United States
UL1 TR000005 / TR / NCATS NIH HHS / United States